About this role
Role Overview
Validate protein target assignments in large-scale bioactivity databases, including ChEMBL and BindingDB, by reviewing primary scientific literature and applying sound scientific judgment. Your evidence-based assessments of whether UniProt IDs match the proteins studied will support AI-driven drug discovery work.
Key Responsibilities
- Review papers and patents to verify protein target assignments against UniProt records.
- Identify and classify target-assignment errors using a structured taxonomy.
- Recommend corrected UniProt accessions when an assignment is inaccurate.
- Prepare concise, evidence-grounded notes that document the reasoning behind each assessment.
Qualifications
- BA/BS with 5+ years of experience, MS with 2+ years of experience, or a PhD with industry or drug discovery research experience in pharmacology, biochemistry, molecular biology, or chemical biology at a biotech, pharmaceutical company, or CRO.
- Current bench-active experience in a research scientist, scientist, or associate scientist role.
- Hands-on experience with binding or functional assays, such as SPR, TR-FRET, radioligand binding, kinase assays, GPCR functional assays, and IC50, Ki, or KD measurements.
- Working fluency with UniProt or related workflows, including SAR support, HTS, target validation, biochemical profiling, or IND-enabling studies.
Preferred Qualifications
- Experience with ChEMBL, BindingDB, or PubChem.
- Selectivity profiling or counterscreening experience.
- Familiarity with the distinctions between agonists and antagonists, and activators and inhibitors.
Work Terms
- Remote, hourly engagement with an immediate start.
- 10-20 hours per week.
- Minimum commitment of 1-2 months.
Compensation
$60-$100 per hour.
Eligibility
Open to candidates located in the United States only.